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SURMOUNT-1 (Jastreboff et al., NEJM 2022) reported 22.5% body weight loss at 72 weeks at the 15 mg dose

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Some symptoms, from more minor to severe, impaired judgment and coordination walking difficulty slurred speech mood change behavior change nausea vomiting low body temperature memory loss double vision involuntary eye movement trouble breathing coma respiratory failure heart rhythm changes liver failure Chronic alcohol poisoning leads to alcohol-related liver disease